Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol
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 PubChem ID
CID: 9884685
SID: 26746641
Canonical SMILES
Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
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Compound Formula C19H16N4O3
Compound Structure
Protein Name
 Protein Info 
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Protein Classification
Enzyme
>
Transferase
Uniprot ID
P42336
Gene Name
PIK3CA
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  4
1
IC50 = 17.9 nM
   TI
   LI
   LO
   TS
2
IC50 = 74 nM
   TI
   LI
   LO
   TS
3
IC50 = 796.3 nM
   TI
   LI
   LO
   TS
4
IC50 = 1034.4 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.76 nM
2 IC50 = 2 nM
3 IC50 = 3.22 nM
4 IC50 = 3.8 nM
5 IC50 = 3.9 nM
6 IC50 = 4 nM
7 IC50 = 4.4 nM
8 IC50 = 4.5 nM
9 IC50 = 5.8 nM
10 IC50 = 6 nM
11 IC50 = 6.1 nM
12 IC50 = 6.8 nM
13 IC50 = 7.5 nM
14 IC50 = 8 nM
15 IC50 = 8.7 nM
16 IC50 = 11 nM
17 IC50 = 12 nM
18 IC50 = 16.8 nM
19 IC50 = 17 nM
20 IC50 = 19.7 nM
21 IC50 = 75 nM
22 IC50 = 150 nM
23 IC50 = 5300 nM
24 Kd = 1.3 nM
25 Kd = 1.4 nM
26 Kd = 1.5 nM
27 Kd = 2.9 nM
28 Kd = 3 nM
29 Kd = 3.2 nM
30 Kd = 3.4 nM