Brief Information of the Compound and Protein
Compound Name
APO-866
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PubChem ID
CID: 6914657
SID: 14780790
Canonical SMILES
O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)\C=C\c1cccnc1
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Compound Formula C24H29N3O2
Compound Structure
Protein Name
Nicotinamide phosphoribosyltransferase
Protein Classification
Enzyme
Uniprot ID
P43490
Gene Name
NAMPT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000072 A2780 Homo sapiens (Human)  1
1
IC50 = 1 nM
   TI
   LI
   LO
   TS
CL000154 HEK293-EBNA1-6E Homo sapiens (Human)  1
1
IC50 = 5 nM
   TI
   LI
   LO
   TS
CL000063 Hep-G2 Homo sapiens (Human)  1
1
IC50 = 2.2 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3 nM
2 IC50 = 6.8 nM
3 IC50 = 9 nM
4 IC50 = 20.7 nM
5 IC50 = 32 nM
6 IC50 = 35 nM
7 IC50 = 14800 nM
8 Ki = 0.3 nM
9 Ki = 3 nM