Brief Information of the Compound and Protein
Compound Name
 Compound Info 
US8530648, 97
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 PubChem ID
CID: 53259636
SID: 124400950
Canonical SMILES
O=C1CCCC2(CCN(CC2)c2cnc3ccccc3n2)N1Cc1c[nH]c2ccccc12
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Compound Formula C26H27N5O
Compound Structure
Protein Name
 Protein Info 
Orexin/Hypocretin receptor type 1
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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Orexin receptor
Uniprot ID
O43613
Gene Name
HCRTR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 275.42 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Kd = 205 nM
2 Ki = 236 nM