Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine
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 PubChem ID
CID: 2995
SID: 14774838
Canonical SMILES
CNCCCN1c2ccccc2CCc2ccccc12
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Compound Formula C18H22N2
Compound Structure
Protein Name
 Protein Info 
Sodium-dependent noradrenaline transporter
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC06 neurotransmitter transporter family
Uniprot ID
P23975
Gene Name
SLC6A2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 4.2 nM
   TI
   LI
   LO
   TS
2
Ki = 2.5 nM
   TI
   LI
   LO
   TS
CL000031 MDCK
 Cell Line Info 
Canis lupus familiaris (Dog)  4
1
IC50 = 0.93 nM
   TI
   LI
   LO
   TS
2
IC50 = 1.5 nM
   TI
   LI
   LO
   TS
3
IC50 = 3.9 nM
   TI
   LI
   LO
   TS
4
Ki = 0.92 nM
   TI
   LI
   LO
   TS
CL000882 MDCK-Net6
 Cell Line Info 
Canis lupus familiaris (Dog)  4
1
IC50 = 3.3 nM
   TI
   LI
   LO
   TS
2
IC50 = 3.4 nM
   TI
   LI
   LO
   TS
3
Ki = 2.1 nM
   TI
   LI
   LO
   TS
4
Ki = 3.4 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3.917 nM
2 Kd = 0.83 nM
3 Ki = 0.6 nM
4 Ki = 1 nM
5 Ki = 5.11 nM
6 Ki = 580 nM