Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-Anilinoquinazoline deriv. 45
    Show/Hide
 PubChem ID
CID: 5328042
SID: 15247974
Canonical SMILES
Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
    Show/Hide
Compound Formula C14H11BrN4
Compound Structure
Protein Name
 Protein Info 
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000052 A-431
 Cell Line Info 
Homo sapiens (Human)  4
1
IC50 = 0.78 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.79 nM
   TI
   LI
   LO
   TS
3
IC50 = 30 nM
   TI
   LI
   LO
   TS
4
IC50 > 10000 nM
   TI
   LI
   LO
   TS
CL000068 A-549
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 21.45 nM
   TI
   LI
   LO
   TS
2
IC50 > 20000 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 40 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 44 nM
2 IC50 = 53 nM