Brief Information of the Compound and Protein
Compound Name
3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
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PubChem ID
CID: 24826799
SID: 49848164
Canonical SMILES
CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
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Compound Formula C29H27F3N6O
Compound Structure
Protein Name
Mast/stem cell growth factor receptor Kit
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P10721
Gene Name
KIT
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000122 GIST-T1 Homo sapiens (Human)  2
1
GI50 = 2.2 nM
   TI
   LI
   LO
   TS
2
GI50 = 9.6 nM
   TI
   LI
   LO
   TS
CL000123 GIST430 Homo sapiens (Human)  1
1
GI50 = 149 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.7 nM
2 IC50 = 4.9 nM
3 IC50 = 8 nM