Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(2R)-2-[(8R)-1-chloro-3-ethyl-8-[2-[3-fluoro-4-(trifluoromethyl)phenyl]ethyl]-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl]-N-methyl-2-phenylacetamide
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 PubChem ID
CID: 66733985
Canonical SMILES
CCc1nc(Cl)c2[C@@H](CCc3ccc(c(F)c3)C(F)(F)F)N(CCn12)[C@@H](C(=O)NC)c1ccccc1
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Compound Formula C26H27ClF4N4O
Compound Structure
Protein Name
 Protein Info 
Orexin/Hypocretin receptor type 1
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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Orexin receptor
Uniprot ID
O43613
Gene Name
HCRTR1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 547 nM
   TI
   LI
   LO
   TS