Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5-[[4-(methylamino)-5-(1-methylpyrazol-4-yl)pyridin-2-yl]amino]-3-[(3S)-1-methylpyrrolidin-3-yl]oxypyrazine-2-carbonitrile
    Show/Hide
 PubChem ID
CID: 71450379
SID: 163507128
Canonical SMILES
CNc1cc(Nc2cnc(C#N)c(O[C@H]3CCN(C)C3)n2)ncc1-c1cnn(C)c1
    Show/Hide
Compound Formula C20H23N9O
Compound Structure
Protein Name
 Protein Info 
Serine/threonine-protein kinase Chk1
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CAMK protein kinase group
>
CAMK protein kinase CAMK1 family
>
CAMK protein kinase CHK1 subfamily
Uniprot ID
O14757
Gene Name
CHEK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000007 HT-29
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 135 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 3.4 nM