Brief Information of the Compound and Protein
Compound Name
N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-6-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1-propan-2-ylindazole-4-carboxamide
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PubChem ID
CID: 67466175
SID: 163513588
Canonical SMILES
CC(C)n1ncc2c(cc(cc12)-c1ccc(nc1)N1CCN(C)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
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Compound Formula C29H35N7O2
Compound Structure
Protein Name
Histone-lysine N-methyltransferase EZH2
Protein Classification
Epigenetic regulator
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Protein methyltransferase
Uniprot ID
Q15910
Gene Name
EZH2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000286 HCC1806 Homo sapiens (Human)  1
1
IC50 = 324 nM
   TI
   LI
   LO
   TS
CL000141 LNCaP Homo sapiens (Human)  1
1
IC50 = 4500 nM
   TI
   LI
   LO
   TS