Brief Information of the Compound and Protein
Compound Name
 Compound Info 
6-fluoro-N-[[1-[(4-hydroxyoxan-4-yl)methyl]piperidin-4-yl]methyl]-2-oxo-3-propan-2-ylbenzimidazole-1-carboxamide
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 PubChem ID
CID: 11166796
SID: 16246331
Canonical SMILES
CC(C)n1c2ccc(F)cc2n(C(=O)NCC2CCN(CC3(O)CCOCC3)CC2)c1=O
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Compound Formula C23H33FN4O4
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 4
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
Q13639
Gene Name
HTR4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
Ki = 4.9 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  7
1
EC50 = 0.38 nM
   TI
   LI
   LO
   TS
2
EC50 = 0.9 nM
   TI
   LI
   LO
   TS
3
EC50 = 0.98 nM
   TI
   LI
   LO
   TS
4
EC50 = 1.2 nM
   TI
   LI
   LO
   TS
5
Ki = 1.7 nM
   TI
   LI
   LO
   TS
6
Ki = 4.4 nM
   TI
   LI
   LO
   TS
7
Ki = 5.5 nM
   TI
   LI
   LO
   TS