Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione

Show/Hide

PubChem ID

CID: 5311037

SID: 12014869

Canonical SMILES	CCn1c2nc(\C=C\c3ccc(OC)c(OC)c3)n(C)c2c(=O)n(CC)c1=O Show/Hide
Compound Formula	C20H24N4O4

Compound Structure

Protein Name

Protein Info

Adenosine receptor A2a

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Small molecule receptor (family A GPCR)

Nucleotide-like receptor (family A GPCR)

Adenosine receptor

Uniprot ID

P29274

Gene Name

ADORA2A

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	4
1	Ki = 12 nM	TI LI LO TS
2	Ki = 36 nM	TI LI LO TS
3	Ki = 90.8 nM	TI LI LO TS
4	Ki = 91.2 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	6
1	Kd = 1258.93 nM	TI LI LO TS
2	Ki = 2.2 nM	TI LI LO TS
3	Ki = 6 nM	TI LI LO TS
4	Ki = 47.4 nM	TI LI LO TS
5	Ki = 91.2 nM	TI LI LO TS
6	Ki = 199.53 nM	TI LI LO TS

Biochemical Assays