Brief Information of the Compound and Protein
Compound Name
 Compound Info 
INCB-018424
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 PubChem ID
CID: 25126798
SID: 81071277
Canonical SMILES
N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12
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Compound Formula C17H18N6
Compound Structure
Protein Name
 Protein Info 
Tyrosine-protein kinase JAK3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase JakB family
Uniprot ID
P52333
Gene Name
JAK3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000012 Sf21
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 428 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 51 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 2.8 nM
2 IC50 = 10.7 nM
3 IC50 = 14.6 nM
4 IC50 = 20.7 nM
5 IC50 = 428 nM
6 IC50 = 430 nM
7 IC50 = 487 nM
8 IC50 = 1940 nM
9 IC50 > 300 nM
10 IC50 > 400 nM
11 IC50 >= 8000 nM
12 Kd = 2 nM
13 Ki = 3.2 nM
14 Ki = 3.22 nM