Brief Information of the Compound and Protein
Compound Name
 Compound Info 
()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane
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 PubChem ID
CID: 1204
SID: 14773265
Canonical SMILES
Clc1ccc(cn1)C1CC2CCC1N2
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Compound Formula C11H13ClN2
Compound Structure
Protein Name
 Protein Info 
Neuronal acetylcholine receptor subunit alpha-7
Protein Classification
Ion channel
>
Ligand-gated ion channel
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Nicotinic acetylcholine receptor
>
Nicotinic acetylcholine receptor alpha subunit
Uniprot ID
P36544
Gene Name
CHRNA7
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
Kd = 6.31 nM
   TI
   LI
   LO
   TS
2
Ki = 2.7 nM
   TI
   LI
   LO
   TS
CL000004 SH-SY5Y
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 31 nM
   TI
   LI
   LO
   TS
2
Kd = 1.06 nM
   TI
   LI
   LO
   TS
3
Ki = 10 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 3500 nM
2 ED50 = 1100 nM
3 Ki = 25 nM