Brief Information of the Compound and Protein
Compound Name
7-(furan-2-yl)-4-piperazin-1-ylquinazolin-2-amine
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PubChem ID
CID: 56835171
SID: 134961881
Canonical SMILES
Nc1nc(N2CCNCC2)c2ccc(cc2n1)-c1ccco1
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Compound Formula C16H17N5O
Compound Structure
Protein Name
Histamine H4 receptor
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Monoamine receptor
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Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T Homo sapiens (Human)  2
1
IC50 = 106 nM
   TI
   LI
   LO
   TS
2
Ki = 7 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  3
1
Kd = 40.74 nM
   TI
   LI
   LO
   TS
2
Ki = 15.14 nM
   TI
   LI
   LO
   TS
3
Ki = 16 nM
   TI
   LI
   LO
   TS