Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

CAS_75921-69-6

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PubChem ID

CID: 91898441

SID: 16544557

Canonical SMILES	CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O Show/Hide
Compound Formula	C78H111N21O19

Compound Structure

Protein Name

Protein Info

Melanocortin receptor 5

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Peptide receptor (family A GPCR)

Short peptide receptor (family A GPCR)

Melanocortin receptor

Uniprot ID

P33032

Gene Name

MC5R

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000404	BHK570 Cell Line Info	Mesocricetus auratus (Golden hamster)	1
1	Ki = 0.48 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	5
1	EC50 = 0.4 nM	TI LI LO TS
2	EC50 = 1 nM	TI LI LO TS
3	EC50 = 1.1 nM	TI LI LO TS
4	IC50 = 2.2 nM	TI LI LO TS
5	Ki = 9.9 nM	TI LI LO TS
CL000309	NCTC clone 929 Cell Line Info	Mus musculus (Mouse)	2
1	EC50 = 0.58 nM	TI LI LO TS
2	IC50 = 0.89 nM	TI LI LO TS

Biochemical Assays

1	IC50 = 0.86 nM
2	IC50 = 2.2 nM