Brief Information of the Compound and Protein
Compound Name
 Compound Info 
5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-indole
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 PubChem ID
CID: 4908365
SID: 125299313
Canonical SMILES
CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
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Compound Formula C14H16ClN3O
Compound Structure
Protein Name
 Protein Info 
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
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Monoamine receptor
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Histamine receptor
Uniprot ID
Q91ZY1
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 4.266 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  3
1
EC50 = 2.57 nM
   TI
   LI
   LO
   TS
2
EC50 = 42.66 nM
   TI
   LI
   LO
   TS
3
Ki = 2.692 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 741.31 nM
2 Ki = 2.4 nM
3 Ki = 6 nM