Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine
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 PubChem ID
CID: 24745335
SID: 49639065
Canonical SMILES
CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(N)n1
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Compound Formula C13H22N6
Compound Structure
Protein Name
 Protein Info 
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Monoamine receptor
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Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 6.166 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  5
1
IC50 = 53.7 nM
   TI
   LI
   LO
   TS
2
Kd = 25.12 nM
   TI
   LI
   LO
   TS
3
Ki = 1.56 nM
   TI
   LI
   LO
   TS
4
Ki = 2.4 nM
   TI
   LI
   LO
   TS
5
Ki = 10.23 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 2.4 nM