Brief Information of the Compound and Protein
Compound Name
 Compound Info 
N-{2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl}-N-(2-pyridinyl)cyclohexane carboxamide trihydrochloride
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 PubChem ID
CID: 104911
SID: 14861034
Canonical SMILES
COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1.Cl.Cl.Cl
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Compound Formula C25H37Cl3N4O2
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 1A
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P08908
Gene Name
HTR1A
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  6
1
IC50 = 4.04 nM
   TI
   LI
   LO
   TS
2
IC50 = 7.06 nM
   TI
   LI
   LO
   TS
3
IC50 = 7.1 nM
   TI
   LI
   LO
   TS
4
IC50 = 8.4 nM
   TI
   LI
   LO
   TS
5
Ki = 0.9 nM
   TI
   LI
   LO
   TS
6
Ki = 0.96 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 37 nM
   TI
   LI
   LO
   TS
CL000065 HEK293-EBNA
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 0.91 nM
   TI
   LI
   LO
   TS
2
Ki = 0.39 nM
   TI
   LI
   LO
   TS
3
Ki = 0.6 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.6 nM