Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1-[[(1R)-1-cyclobutyl-2,2,2-trifluoroethyl]amino]-7-(1-methylpyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide
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 PubChem ID
CID: 56595053
SID: 134226857
Canonical SMILES
Cn1cc(cn1)-c1ccc2c(c1)[nH]c1c(cnc(N[C@H](C3CCC3)C(F)(F)F)c21)C(N)=O
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Compound Formula C22H21F3N6O
Compound Structure
Protein Name
 Protein Info 
Tyrosine-protein kinase JAK2
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase JakB family
Uniprot ID
O60674
Gene Name
JAK2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000082 HEL
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 350 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 12 nM