Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
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 PubChem ID
CID: 11626560
SID: 16729581
Canonical SMILES
C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
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Compound Formula C21H22Cl2FN5O
Compound Structure
Protein Name
 Protein Info 
Hepatocyte growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Met family
Uniprot ID
P08581
Gene Name
MET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 8 nM
   TI
   LI
   LO
   TS
CL000413 MKN45
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 20 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 0.51 nM
2 IC50 = 0.78 nM
3 IC50 = 0.9 nM
4 IC50 < 1 nM
5 IC50 = 1.053 nM
6 IC50 = 1.1 nM
7 IC50 = 1.4 nM
8 IC50 = 1.5 nM
9 IC50 = 1.6 nM
10 IC50 = 2 nM
11 IC50 = 2.4 nM
12 IC50 = 2.93 nM
13 IC50 = 3 nM
14 IC50 = 3.2 nM
15 IC50 = 4 nM
16 IC50 = 7.1 nM
17 IC50 = 8 nM
18 IC50 = 8.29 nM
19 IC50 = 11 nM
20 IC50 = 16 nM
21 Kd = 0.2 nM
22 Kd = 0.55 nM
23 Kd = 1.5 nM
24 Kd = 2 nM
25 Kd = 2.1 nM
26 Ki = 2 nM
27 Ki = 4 nM