Brief Information of the Compound and Protein
Compound Name
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
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PubChem ID
CID: 11626560
SID: 16729581
Canonical SMILES
C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
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Compound Formula C21H22Cl2FN5O
Compound Structure
Protein Name
Insulin receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase InsR family
Uniprot ID
P06213
Gene Name
INSR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 = 1643 nM
   TI
   LI
   LO
   TS
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 2887 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 102 nM
2 IC50 = 201 nM
3 IC50 = 650 nM
4 Kd = 340 nM