Brief Information of the Compound and Protein
Compound Name
rac-N-(biphenyl-2-yl)-2-(2,3-dihydro-1H-inden-2-yl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazine-7(1H)-carboxamide
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PubChem ID
CID: 56659615
Canonical SMILES
O=C(Nc1ccccc1-c1ccccc1)N1CCN2C(=O)N(C3Cc4ccccc4C3)C(=O)C2C1
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Compound Formula C28H26N4O3
Compound Structure
Protein Name
Protein smoothened
Protein Classification
Membrane receptor
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Frizzled family G protein-coupled receptor
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Smoothened receptor (frizzled family GPCR)
Uniprot ID
Q99835
Gene Name
SMO
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  1
1
IC50 = 880 nM
   TI
   LI
   LO
   TS
CL000426 Shh Light II Mus musculus (Mouse)  1
1
IC50 = 320 nM
   TI
   LI
   LO
   TS