Brief Information of the Compound and Protein
Compound Name
 Compound Info 
3-oxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(2-phenylphenyl)-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazine-7-carboxamide
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 PubChem ID
CID: 56663266
Canonical SMILES
O=C(Nc1ccccc1-c1ccccc1)N1CCN2C(CN([C@H]3C[C@@H]3c3ccccc3)C2=O)C1
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Compound Formula C28H28N4O2
Compound Structure
Protein Name
 Protein Info 
Protein smoothened
Protein Classification
Membrane receptor
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Frizzled family G protein-coupled receptor
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Smoothened receptor (frizzled family GPCR)
Uniprot ID
Q99835
Gene Name
SMO
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  1
1
IC50 = 1400 nM
   TI
   LI
   LO
   TS
CL000426 Shh Light II
 Cell Line Info 
Mus musculus (Mouse)  1
1
IC50 = 3000 nM
   TI
   LI
   LO
   TS