Brief Information of the Compound and Protein
| Compound Name |
(risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one
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PubChem ID | |||||
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Compound Structure |
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| Protein Name |
5-hydroxytryptamine receptor 2C
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Protein Classification |
Membrane receptor
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Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Monoamine receptor
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Serotonin receptor
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| Uniprot ID | Gene Name | HTR2C |
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Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
| Cell Line ID | Cell Line Name | Cell Line Organism | |
| CL000011 | CHO | Cricetulus griseus (Chinese hamster) | 1 |
| 1 |
Ki = 12.59 nM
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TI
LI
LO
TS
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|---|---|---|---|
| CL000027 | tsA201 | Homo sapiens (Human) | 1 |
| 1 |
Ki = 33 nM
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TI
LI
LO
TS
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Biochemical Assays
| 1 | IC50 = 1.81 nM | ||
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| 2 | IC50 = 7 nM | ||
| 3 | Ki = 6.4 nM | ||
| 4 | Ki = 7.413 nM | ||
| 5 | Ki = 10 nM | ||
| 6 | Ki = 12 nM | ||
| 7 | Ki = 20.9 nM | ||
| 8 | Ki = 32 nM | ||
| 9 | Ki = 39.1 nM | ||
| 10 | Ki = 41.69 nM | ||
| 11 | Ki = 63 nM | ||
| 12 | Ki = 91.2 nM | ||
| 13 | Ki = 100 nM | ||