Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-benzenesulfonamide
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 PubChem ID
CID: 5312145
SID: 14752063
Canonical SMILES
CNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(NC)n1
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Compound Formula C12H16N6O2S
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 6
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P50406
Gene Name
HTR6
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  4
1
Ki = 44.7 nM
   TI
   LI
   LO
   TS
2
Ki = 47 nM
   TI
   LI
   LO
   TS
3
Ki = 50 nM
   TI
   LI
   LO
   TS
4
Ki = 55 nM
   TI
   LI
   LO
   TS
CL000017 HeLa
 Cell Line Info 
Homo sapiens (Human)  2
1
Ki = 50.12 nM
   TI
   LI
   LO
   TS
2
Ki = 55 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 26.3 nM
2 Ki = 50.12 nM
3 Ki = 54.95 nM
4 Ki = 55 nM
5 Ki = 58 nM