Brief Information of the Compound and Protein
Compound Name
 Compound Info 
2-Methyl-6-(phenylethynyl)pyridine
    Show/Hide
 PubChem ID
CID: 3025961
SID: 56310595
Canonical SMILES
Cc1cccc(n1)C#Cc1ccccc1
    Show/Hide
Compound Formula C14H11N
Compound Structure
Protein Name
 Protein Info 
Metabotropic glutamate receptor 5
Protein Classification
Membrane receptor
>
Family C G protein-coupled receptor
>
Small molecule receptor (family C GPCR)
>
Neurotransmitter receptor (family C GPCR)
>
Metabotropic glutamate receptor
Uniprot ID
P31424
Gene Name
GRM5
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 0.2 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 3.54 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 2.93 nM
   TI
   LI
   LO
   TS
2
Ki = 18.7 nM
   TI
   LI
   LO
   TS
CL000050 HEK293-A
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 3.54 nM
   TI
   LI
   LO
   TS
2
IC50 = 31 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 36 nM
2 Ki = 4.7 nM
3 Ki = 13 nM