Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine
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 PubChem ID
CID: 11658860
SID: 16769280
Canonical SMILES
C[C@H]1CNCCc2ccc(Cl)cc12
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Compound Formula C11H14ClN
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 2C
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P28335
Gene Name
HTR2C
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
EC50 = 210 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
Ki = 15 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  6
1
EC50 = 2.7 nM
   TI
   LI
   LO
   TS
2
EC50 = 3.6 nM
   TI
   LI
   LO
   TS
3
EC50 = 7.943 nM
   TI
   LI
   LO
   TS
4
EC50 = 9 nM
   TI
   LI
   LO
   TS
5
EC50 = 11 nM
   TI
   LI
   LO
   TS
6
Ki = 15 nM
   TI
   LI
   LO
   TS
CL000035 NIH 3T3
 Cell Line Info 
Mus musculus (Mouse)  1
1
Ki = 167 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 9 nM
2 Ki = 15 nM
3 Ki = 257 nM