Brief Information of the Compound and Protein
Compound Name
(S)-5-fluoro-4-hydroxy-1-(3-oxo-3,6-dihydro-2H-pyran-2-yl)pyrimidin-2(1H)-one
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PubChem ID
CID: 52916693
SID: 123052969
Canonical SMILES
Fc1cn([C@H]2OCC=CC2=O)c(=O)[nH]c1=O
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Compound Formula C9H7FN2O4
Compound Structure
Protein Name
Thymidylate synthase
Protein Classification
Enzyme
>
Transferase
Uniprot ID
P07607
Gene Name
TYMS
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000266 L1210 Mus musculus (Mouse)  6
1
IC50 = 63 nM
   TI
   LI
   LO
   TS
2
IC50 = 71 nM
   TI
   LI
   LO
   TS
3
IC50 = 830 nM
   TI
   LI
   LO
   TS
4
IC50 = 950 nM
   TI
   LI
   LO
   TS
5
IC50 = 8100 nM
   TI
   LI
   LO
   TS
6
IC50 > 10000 nM
   TI
   LI
   LO
   TS