Brief Information of the Compound and Protein
Compound Name
5-fluoro-1-[(6S)-5-methylidene-2H-pyran-6-yl]pyrimidine-2,4-dione
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PubChem ID
CID: 52915108
SID: 123051313
Canonical SMILES
Fc1cn([C@H]2OCC=CC2=C)c(=O)[nH]c1=O
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Compound Formula C10H9FN2O3
Compound Structure
Protein Name
Thymidylate synthase
Protein Classification
Enzyme
>
Transferase
Uniprot ID
P07607
Gene Name
TYMS
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000266 L1210 Mus musculus (Mouse)  5
1
IC50 = 430 nM
   TI
   LI
   LO
   TS
2
IC50 = 2200 nM
   TI
   LI
   LO
   TS
3
IC50 = 8700 nM
   TI
   LI
   LO
   TS
4
IC50 = 9300 nM
   TI
   LI
   LO
   TS
5
IC50 > 10000 nM
   TI
   LI
   LO
   TS