Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]phenyl}-4,5-dimethoxy-2-(3-quinolylcarboxamido)benzamide
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 PubChem ID
CID: 148201
SID: 14765736
Canonical SMILES
COc1cc2CCN(CCc3ccc(NC(=O)c4cc(OC)c(OC)cc4NC(=O)c4cnc5ccccc5c4)cc3)Cc2cc1OC
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Compound Formula C38H38N4O6
Compound Structure
Protein Name
 Protein Info 
Broad substrate specificity ATP-binding cassette transporter ABCG2
Protein Classification
Transporter
>
Primary active transporter
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ATP-binding cassette
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ABCG subfamily
Uniprot ID
Q9UNQ0
Gene Name
ABCG2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1445.44 nM
   TI
   LI
   LO
   TS
CL000756 MCF/MX
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 680 nM
   TI
   LI
   LO
   TS
2
IC50 = 1500 nM
   TI
   LI
   LO
   TS
CL000781 MCF7/Topo
 Cell Line Info 
Homo sapiens (Human)  3
1
IC50 = 520 nM
   TI
   LI
   LO
   TS
2
IC50 = 526 nM
   TI
   LI
   LO
   TS
3
IC50 = 916 nM
   TI
   LI
   LO
   TS
CL000031 MDCK
 Cell Line Info 
Canis lupus familiaris (Dog)  3
1
EC50 = 10 nM
   TI
   LI
   LO
   TS
2
IC50 = 850 nM
   TI
   LI
   LO
   TS
3
IC50 = 940 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 100 nM
2 IC50 = 183.3 nM