Brief Information of the Compound and Protein
Compound Name
2-chloro-N-(1-(3-methyl-4-(6-oxo-5,9-bis(2,2,2-trifluoroethoxy)-6H-pyrrolo[3,4-g]quinolin-7(8H)-yl)benzyl)cyclopropylcarbamoyl)benzenesulfonamide
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PubChem ID
CID: 24944538
Canonical SMILES
Cc1cc(CC2(CC2)NC(=O)NS(=O)(=O)c2ccccc2Cl)ccc1N1Cc2c(C1=O)c(OCC(F)(F)F)c1cccnc1c2OCC(F)(F)F
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Compound Formula C33H27ClF6N4O6S
Compound Structure
Protein Name
Prostaglandin E2 receptor EP4 subtype
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Lipid-like ligand receptor (family A GPCR)
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Prostanoid receptor
Uniprot ID
P35408
Gene Name
PTGER4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  4
1
IC50 = 3 nM
   TI
   LI
   LO
   TS
2
IC50 = 48 nM
   TI
   LI
   LO
   TS
3
Ki = 0.48 nM
   TI
   LI
   LO
   TS
4
Ki = 14 nM
   TI
   LI
   LO
   TS