Brief Information of the Compound and Protein
Compound Name
N-[1-[[4-(4,9-diethoxy-3-oxo-1H-benzo[f]isoindol-2-yl)-3-methylphenyl]methyl]cyclopropyl]-2-(3-methoxypyridin-2-yl)acetamide
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PubChem ID
CID: 53325765
Canonical SMILES
CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)Cc2ncccc2OC)cc1C
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Compound Formula C35H37N3O5
Compound Structure
Protein Name
Prostaglandin E2 receptor EP4 subtype
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Lipid-like ligand receptor (family A GPCR)
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Prostanoid receptor
Uniprot ID
P35408
Gene Name
PTGER4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  4
1
IC50 = 4.9 nM
   TI
   LI
   LO
   TS
2
IC50 = 23.6 nM
   TI
   LI
   LO
   TS
3
Ki = 0.16 nM
   TI
   LI
   LO
   TS
4
Ki = 1.44 nM
   TI
   LI
   LO
   TS