Brief Information of the Compound and Protein
Compound Name
4-[5-chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amine
    Show/Hide
PubChem ID
CID: 49800100
SID: 104166653
Canonical SMILES
CC(C)c1n[nH]c(Cl)c1-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1
    Show/Hide
Compound Formula C19H23ClN8
Compound Structure
Protein Name
Cyclin-dependent kinase 4
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
CMGC protein kinase group
Uniprot ID
P11802
Gene Name
CDK4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000182 JeKo-1 Homo sapiens (Human)  2
1
IC50 = 223 nM
   TI
   LI
   LO
   TS
2
IC50 = 467 nM
   TI
   LI
   LO
   TS