Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
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 PubChem ID
CID: 216239
SID: 14834034
Canonical SMILES
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
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Compound Formula C21H16ClF3N4O3
Compound Structure
Protein Name
 Protein Info 
Receptor-type tyrosine-protein kinase FLT3
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase PDGFR family
Uniprot ID
P36888
Gene Name
FLT3
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
Kd = 13 nM
   TI
   LI
   LO
   TS
CL000071 MOLM-13
 Cell Line Info 
Homo sapiens (Human)  1
1
GI50 = 56 nM
   TI
   LI
   LO
   TS
CL000091 MV4-11
 Cell Line Info 
Homo sapiens (Human)  2
1
GI50 = 43 nM
   TI
   LI
   LO
   TS
2
IC50 = 7 nM
   TI
   LI
   LO
   TS
CL000120 RS4;11
 Cell Line Info 
Homo sapiens (Human)  3
1
GI50 = 9300 nM
   TI
   LI
   LO
   TS
2
IC50 = 2 nM
   TI
   LI
   LO
   TS
3
IC50 = 3.2 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
IC50 = 44 nM
   TI
   LI
   LO
   TS
2
IC50 = 54 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 1.3 nM
2 IC50 = 2.8 nM
3 IC50 = 4 nM
4 IC50 = 15.48 nM
5 IC50 = 32.6 nM
6 IC50 = 33 nM
7 IC50 = 54 nM
8 IC50 = 58 nM
9 IC50 = 62 nM
10 IC50 = 103.5 nM
11 Kd = 4.5 nM
12 Kd = 11 nM
13 Kd = 13 nM
14 Kd = 17 nM
15 Kd = 20 nM
16 Kd = 30 nM
17 Kd = 79 nM
18 Kd = 82 nM