Brief Information of the Compound and Protein
Compound Name
(S)-5-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4]triazin-2-yl)-1-(6-fluoronicotinoyl)pyrrolidin-2-one
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PubChem ID
CID: 25101637
SID: 56421369
Canonical SMILES
Fc1ccc(cn1)C(=O)N1[C@@H](CCC1=O)c1nc(Nc2cc(n[nH]2)C2CC2)c2cccn2n1
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Compound Formula C22H19FN8O2
Compound Structure
Protein Name
Insulin-like growth factor 1 receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase InsR family
Uniprot ID
P08069
Gene Name
IGF1R
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000899 IGFSal Homo sapiens (Human)  1
1
IC50 = 508 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 11 nM