Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-{1-[({2,5-Dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}-carbonyl)amino]cyclopropyl}benzoic Acid
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 PubChem ID
CID: 24952929
SID: 56250754
Canonical SMILES
Cc1sc(C)c(C(=O)NC2(CC2)c2ccc(cc2)C(O)=O)c1Cc1ccc(cc1)C(F)(F)F
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Compound Formula C25H22F3NO3S
Compound Structure
Protein Name
 Protein Info 
Prostaglandin E2 receptor EP4 subtype
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Lipid-like ligand receptor (family A GPCR)
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Prostanoid receptor
Uniprot ID
P35408
Gene Name
PTGER4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000076 CHO/Galpha16
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 2.5 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
IC50 = 2.5 nM
   TI
   LI
   LO
   TS
2
IC50 = 2.9 nM
   TI
   LI
   LO
   TS
CL000065 HEK293-EBNA
 Cell Line Info 
Homo sapiens (Human)  2
1
Ki = 0.56 nM
   TI
   LI
   LO
   TS
2
Ki = 0.97 nM
   TI
   LI
   LO
   TS