Brief Information of the Compound and Protein
Compound Name
N-[4-(3-bromoanilino)quinazolin-6-yl]-2-(2,3,4,5,6-pentafluorophenoxy)acetamide
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PubChem ID
CID: 45141141
SID: 92391094
Canonical SMILES
Fc1c(F)c(F)c(OCC(=O)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)c(F)c1F
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Compound Formula C22H12BrF5N4O2
Compound Structure
Protein Name
Epidermal growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase EGFR family
Uniprot ID
P00533
Gene Name
EGFR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000052 A-431 Homo sapiens (Human)  2
1
IC50 = 78 nM
   TI
   LI
   LO
   TS
2
IC50 = 84 nM
   TI
   LI
   LO
   TS
CL000068 A-549 Homo sapiens (Human)  2
1
IC50 = 49.8 nM
   TI
   LI
   LO
   TS
2
IC50 = 118 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 23.6 nM