Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R)-N-(2-(1-(4-chlorobenzyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide
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 PubChem ID
CID: 44453327
Canonical SMILES
FC(F)(F)c1cccc(c1)C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1
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Compound Formula C21H21ClF3N3O2
Compound Structure
Protein Name
 Protein Info 
C-C chemokine receptor type 2
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Chemokine receptor
>
CC chemokine receptor
Uniprot ID
P41597
Gene Name
CCR2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 980 nM
   TI
   LI
   LO
   TS
CL000065 HEK293-EBNA
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 3200 nM
   TI
   LI
   LO
   TS
CL000040 THP-1
 Cell Line Info 
Homo sapiens (Human)  4
1
EC50 = 20 nM
   TI
   LI
   LO
   TS
2
IC50 = 24 nM
   TI
   LI
   LO
   TS
3
IC50 = 180 nM
   TI
   LI
   LO
   TS
4
IC50 > 300 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 180 nM