Brief Information of the Compound and Protein
Compound Name
 Compound Info 
WAY-362450
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 PubChem ID
CID: 10026128
SID: 123055418
Canonical SMILES
CC(C)OC(=O)C1=CN(CC(C)(C)c2c1[nH]c1ccccc21)C(=O)c1ccc(F)c(F)c1
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Compound Formula C25H24F2N2O3
Compound Structure
Protein Name
 Protein Info 
Bile acid receptor
Protein Classification
Transcription factor
>
Nuclear receptor
>
Nuclear hormone receptor subfamily 1
>
Nuclear hormone receptor subfamily 1 group H
>
Nuclear hormone receptor subfamily 1 group H member 4
Uniprot ID
Q96RI1
Gene Name
NR1H4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000044 CV-1
 Cell Line Info 
Chlorocebus aethiops (Green monkey)  4
1
EC50 = 4 nM
   TI
   LI
   LO
   TS
2
EC50 = 17 nM
   TI
   LI
   LO
   TS
3
EC50 = 33 nM
   TI
   LI
   LO
   TS
4
EC50 = 230 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
EC50 = 15 nM
   TI
   LI
   LO
   TS
2
EC50 = 16 nM
   TI
   LI
   LO
   TS