Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)-butyl]-thiophene-2-carbonyl}-amino)-pentanedioicAcid
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 PubChem ID
CID: 135567028
SID: 96032811
Canonical SMILES
Nc1nc2[nH]c(CCCCc3ccc(s3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
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Compound Formula C20H23N5O6S
Compound Structure
Protein Name
 Protein Info 
Proton-coupled folate transporter
Protein Classification
Transporter
>
Electrochemical transporter
>
SLC superfamily of solute carriers
>
SLC46 family of folate transporters
Uniprot ID
Q96NT5
Gene Name
SLC46A1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000330 CHO Pro-4 MtxRII OuaR-2-4
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  4
1
Ki = 130 nM
   TI
   LI
   LO
   TS
2
Ki = 230 nM
   TI
   LI
   LO
   TS
3
Ki = 1950 nM
   TI
   LI
   LO
   TS
4
Ki = 7230 nM
   TI
   LI
   LO
   TS
CL000937 R2/PCFT4
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 43.4 nM
   TI
   LI
   LO
   TS