Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4,4,4-trifluoro-3-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylamino)-N-(2-methoxyphenyl)butanamide
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 PubChem ID
CID: 46232607
Canonical SMILES
COc1ccccc1NC(=O)CC(Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)C(F)(F)F
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Compound Formula C28H23F4N5O3S
Compound Structure
Protein Name
 Protein Info 
Hepatocyte growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Met family
Uniprot ID
P08581
Gene Name
MET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
CL000023 BTI-Tn-5B1-4
 Cell Line Info 
Trichoplusia ni (Cabbage looper)  1
1
IC50 = 840 nM
   TI
   LI
   LO
   TS
CL000119 DU145
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
CL000025 HEK-293T
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1800 nM
   TI
   LI
   LO
   TS