Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one
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 PubChem ID
CID: 10461815
SID: 15483678
Canonical SMILES
Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1
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Compound Formula C32H34Cl2N4O4S
Compound Structure
Protein Name
 Protein Info 
Hepatocyte growth factor receptor
Protein Classification
Enzyme
>
Kinase
>
Protein Kinase
>
TK protein kinase group
>
Tyrosine protein kinase Met family
Uniprot ID
P08581
Gene Name
MET
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 9 nM
   TI
   LI
   LO
   TS
CL000282 GTL-16
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 9 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 38 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 EC50 = 42 nM
2 IC50 = 9 nM
3 IC50 = 38 nM
4 Kd = 0.27 nM
5 Kd = 0.64 nM
6 Kd = 0.83 nM