Brief Information of the Compound and Protein
Compound Name
 Compound Info 
4-N-benzyl-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine
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 PubChem ID
CID: 25130914
SID: 56455292
Canonical SMILES
CN1CCN(CC1)c1cc(NCc2ccccc2)nc(N)n1
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Compound Formula C16H22N6
Compound Structure
Protein Name
 Protein Info 
Histamine H4 receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
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Small molecule receptor (family A GPCR)
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Monoamine receptor
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Histamine receptor
Uniprot ID
Q9H3N8
Gene Name
HRH4
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  1
1
EC50 = 64.57 nM
   TI
   LI
   LO
   TS
CL000013 Sf9
 Cell Line Info 
Spodoptera frugiperda (Fall armyworm)  2
1
EC50 = 21.38 nM
   TI
   LI
   LO
   TS
2
Ki = 98 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 20 nM