Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide
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 PubChem ID
CID: 5358
SID: 14825017
Canonical SMILES
CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
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Compound Formula C14H21N3O2S
Compound Structure
Protein Name
 Protein Info 
5-hydroxytryptamine receptor 1B
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Small molecule receptor (family A GPCR)
>
Monoamine receptor
>
Serotonin receptor
Uniprot ID
P28222
Gene Name
HTR1B
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  3
1
IC50 = 10 nM
   TI
   LI
   LO
   TS
2
IC50 = 11 nM
   TI
   LI
   LO
   TS
3
IC50 = 16 nM
   TI
   LI
   LO
   TS
CL000026 CHO-K1
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  5
1
EC50 = 77 nM
   TI
   LI
   LO
   TS
2
IC50 = 0.5012 nM
   TI
   LI
   LO
   TS
3
Ki = 9.1 nM
   TI
   LI
   LO
   TS
4
Ki = 22 nM
   TI
   LI
   LO
   TS
5
Ki = 23.1 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 27 nM
2 Ki = 7.7 nM
3 Ki = 9.6 nM
4 Ki = 10 nM
5 Ki = 19.1 nM
6 Ki = 23.1 nM
7 Ki = 36 nM
8 Ki = 47.9 nM