Brief Information of the Compound and Protein
Compound Name
 Compound Info 
(S)-[(S)-5-(3-Butyl-phenyl)-2-oxo-1-(2,4,6-trifluoro-benzyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-5-yl]-(4,6-dimethyl-pyrimidin-2-yloxy)-acetic acid
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 PubChem ID
CID: 11308052
SID: 16396553
Canonical SMILES
CCCCc1cccc(c1)[C@@]1(NCC(=O)N(Cc2c(F)cc(F)cc2F)c2ccccc12)[C@H](Oc1nc(C)cc(C)n1)C(O)=O
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Compound Formula C34H33F3N4O4
Compound Structure
Protein Name
 Protein Info 
Endothelin receptor type B
Protein Classification
Membrane receptor
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Family A G protein-coupled receptor
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Peptide receptor (family A GPCR)
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Short peptide receptor (family A GPCR)
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Endothelin receptor
Uniprot ID
P24530
Gene Name
EDNRB
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  1
1
IC50 = 33.2 nM
   TI
   LI
   LO
   TS