Brief Information of the Compound and Protein
Compound Name
 Compound Info 
BUPRENORPHINE
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 PubChem ID
CID: 9848990
SID: 14882841
Canonical SMILES
CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5O[C@@H]2[C@]3(CCN1CC1CC1)c45
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Compound Formula C29H41NO4
Compound Structure
Protein Name
 Protein Info 
Kappa-type opioid receptor
Protein Classification
Membrane receptor
>
Family A G protein-coupled receptor
>
Peptide receptor (family A GPCR)
>
Short peptide receptor (family A GPCR)
>
Opioid receptor
Uniprot ID
P41145
Gene Name
OPRK1
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO
 Cell Line Info 
Cricetulus griseus (Chinese hamster)  8
1
EC50 = 0.18 nM
   TI
   LI
   LO
   TS
2
EC50 > 10000 nM
   TI
   LI
   LO
   TS
3
IC50 = 15 nM
   TI
   LI
   LO
   TS
4
Ki = 0.067 nM
   TI
   LI
   LO
   TS
5
Ki = 0.089 nM
   TI
   LI
   LO
   TS
6
Ki = 0.62 nM
   TI
   LI
   LO
   TS
7
Ki = 0.8 nM
   TI
   LI
   LO
   TS
8
Ki = 2.5 nM
   TI
   LI
   LO
   TS
CL000006 HEK293
 Cell Line Info 
Homo sapiens (Human)  2
1
Ki = 0.04 nM
   TI
   LI
   LO
   TS
2
Ki = 0.07 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 Ki = 0.8 nM