Bioactivity Information

Brief Information of the Compound and Protein

Compound Name

Compound Info

(+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide

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PubChem ID

CID: 123924

SID: 14833255

Canonical SMILES	CCN(CC)C(=O)c1ccc(cc1)[C@@H](N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1cccc(OC)c1 Show/Hide
Compound Formula	C28H39N3O2

Compound Structure

Protein Name

Protein Info

Delta-type opioid receptor

Protein Classification

Membrane receptor

Family A G protein-coupled receptor

Peptide receptor (family A GPCR)

Short peptide receptor (family A GPCR)

Opioid receptor

Uniprot ID

P41143

Gene Name

OPRD1

Table of Molecular Bioactivities Related to the Compound and Protein

Cell-based Assay

Cell Line ID	Cell Line Name	Cell Line Organism
CL000011	CHO Cell Line Info	Cricetulus griseus (Chinese hamster)	11
1	EC50 = 1.9 nM	TI LI LO TS
2	EC50 = 4.8 nM	TI LI LO TS
3	EC50 = 7.6 nM	TI LI LO TS
4	EC50 = 10 nM	TI LI LO TS
5	EC50 = 14.4 nM	TI LI LO TS
6	EC50 = 15.7 nM	TI LI LO TS
7	EC50 = 210 nM	TI LI LO TS
8	ED50 = 26 nM	TI LI LO TS
9	IC50 = 2 nM	TI LI LO TS
10	IC50 = 2.2 nM	TI LI LO TS
11	Ki = 1.2 nM	TI LI LO TS
CL000026	CHO-K1 Cell Line Info	Cricetulus griseus (Chinese hamster)	2
1	Ki = 1.2 nM	TI LI LO TS
2	Ki = 1.7 nM	TI LI LO TS
CL000006	HEK293 Cell Line Info	Homo sapiens (Human)	2
1	EC50 = 1.7 nM	TI LI LO TS
2	EC50 = 15.7 nM	TI LI LO TS
CL000107	HEK293S Cell Line Info	Homo sapiens (Human)	1
1	IC50 = 1.31 nM	TI LI LO TS

Biochemical Assays