Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1,4-benzodiazepine-2,5-dione, 12j
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 PubChem ID
CID: 11952735
SID: 17394136
Canonical SMILES
CC#Cc1ccc2N(CCN3CCOCC3)C(=O)[C@@H](N([C@H](C)c3ccc(Cl)cc3N)C(=O)c2c1)c1ccc(Cl)cc1
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Compound Formula C32H32Cl2N4O3
Compound Structure
Protein Name
 Protein Info 
E3 ubiquitin-protein ligase Mdm2
Protein Classification
Other nuclear protein
Uniprot ID
Q00987
Gene Name
MDM2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1700 nM
   TI
   LI
   LO
   TS
CL000111 MDA-MB-231
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 10000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 787 nM