Brief Information of the Compound and Protein
Compound Name
 Compound Info 
1,4-benzodiazepine-2,5-dione scaffold, 21
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 PubChem ID
CID: 9917797
SID: 14888262
Canonical SMILES
COCCOCCN1c2ccc(I)cc2C(=O)N([C@H](C)c2ccc(Cl)cc2N)[C@@H](c2ccc(Cl)cc2)C1=O
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Compound Formula C28H28Cl2IN3O4
Compound Structure
Protein Name
 Protein Info 
E3 ubiquitin-protein ligase Mdm2
Protein Classification
Other nuclear protein
Uniprot ID
Q00987
Gene Name
MDM2
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000083 MCF-7
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 1100 nM
   TI
   LI
   LO
   TS
CL000111 MDA-MB-231
 Cell Line Info 
Homo sapiens (Human)  1
1
IC50 = 57000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 394 nM
2 IC50 = 700 nM