Brief Information of the Compound and Protein
Compound Name
3-(2'-oxo-1',2'-dihydrospiro[cyclohexane-1,3'-indol]-5'-yl)benzonitrile
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PubChem ID
CID: 9817870
SID: 14776202
Canonical SMILES
O=C1Nc2ccc(cc2C11CCCCC1)-c1cccc(c1)C#N
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Compound Formula C20H18N2O
Compound Structure
Protein Name
Progesterone receptor
Protein Classification
Transcription factor
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Nuclear receptor
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Nuclear hormone receptor subfamily 3
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Nuclear hormone receptor subfamily 3 group C
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Nuclear hormone receptor subfamily 3 group C member 3
Uniprot ID
P06401
Gene Name
PGR
Table of Molecular Bioactivities Related to the Compound and Protein
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000078 T-47D Homo sapiens (Human)  5
1
EC50 ~ 1000 nM
   TI
   LI
   LO
   TS
2
IC50 = 6.6 nM
   TI
   LI
   LO
   TS
3
IC50 = 14.7 nM
   TI
   LI
   LO
   TS
4
IC50 = 15 nM
   TI
   LI
   LO
   TS
5
IC50 = 25 nM
   TI
   LI
   LO
   TS